Rethinking the Ideas about Family Functions

Evolving Ideas about Cyclins

instance, is associated primarily with activation of S James M. Roberts Division of Basic Sciences phase whereas CDK1 primarily with mitosis. However, assays using defined peptides reveal only subtle differFred Hutchinson Cancer Research Center and Howard Hughes Medical Institute ences in substrate preference between CDK1 and CDK2 (Holmes and Solomon, 1996), and there is no compelling 1100 Fair...

Some Ideas About Colour

Emerging Ideas About Categories

The study of human categorization is contentious because it matters. How we understand the processes that give rise to categories is at the very core of how we understand human cognition. Over the past several decades, there has been growing concern that the assumptions that define and distinguish competing theories may notbe quite right. These assumptions are based on the traditional metaphor ...

Changing ideas about eukaryotic origins.

The origin of eukaryotic cells is one of the most fascinating challenges in biology, and has inspired decades of controversy and debate. Recent work has led to major upheavals in our understanding of eukaryotic origins and has catalysed new debates about the roles of endosymbiosis and gene flow across the tree of life. Improved methods of phylogenetic analysis support scenarios in which the hos...

Current Ideas about Prebiological Compartmentalization

Contemporary biological cells are highly sophisticated dynamic compartment systems which separate an internal volume from the external medium through a boundary, which controls, in complex ways, the exchange of matter and energy between the cell's interior and the environment. Since such compartmentalization is a fundamental principle of all forms of life, scenarios have been elaborated about t...